Non-destructive characterization of microdamage in cortical bone using low field pulsed NMR.

نویسندگان

  • Daniel P Nicolella
  • Qingwen Ni
  • Kwai S Chan
چکیده

The microcracking and damage accumulation process in human cortical bone was characterized by performing cyclic loading under four-point bending at ambient temperature. A non-destructive nuclear magnetic resonance (NMR) spin-spin (T(2)) relaxation technique was applied to quantify the apparent changes in bone porosity as a function of cyclic loading and prior damage accumulation, first to unloaded cortical bone to quantify the initial porosity and then to fatigued cortical bone that was subjected to cyclic loading to various levels of modulus degradation and microdamage in the form of microcracks. The NMR T(2) relaxation time and amplitude data of the fatigued bone were compared against the undamaged state. The difference in the T(2) relaxation time data was taken as a measure of the increase in pore size, bone porosity or microcrack density due to microdamage induced by cyclic loading. A procedure was developed to deduce the number and size distributions of microcracks formed in cortical bone. Serial sectioning of the fatigued bone showed the formation of microcracks along the cement lines or within the interstitial tissue. The results on the evolution of microdamage derived from NMR measurements were verified by independent experimental measurements of microcrack density using histological characterization techniques. The size distribution and population of the microcracks were then utilized in conjunction with an analytical model to predict the degradation of the elastic modulus of cortical bone as a function of damage accumulation.

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Micro-computed tomography of fatigue microdamage in cortical bone using a barium sulfate contrast agent.

Accumulation of microdamage during fatigue can lead to increased fracture susceptibility in bone. Current techniques for imaging microdamage in bone are inherently destructive and two-dimensional. Therefore, the objective of this study was to image the accumulation of fatigue microdamage in cortical bone using micro-computed tomography (micro-CT) with a barium sulfate (BaSO(4)) contrast agent. ...

متن کامل

Contrast-enhanced micro-computed tomography of fatigue microdamage accumulation in human cortical bone.

Conventional methods used to image and quantify microdamage accumulation in bone are limited to histological sections, which are inherently invasive, destructive, two-dimensional, and tedious. These limitations inhibit investigation of microdamage accumulation with respect to volumetric spatial variation in mechanical loading, bone mineral density, and microarchitecture. Therefore, the objectiv...

متن کامل

Detection of fatigue microdamage in whole rat femora using contrast-enhanced micro-computed tomography.

Microdamage in bone tissue is typically studied using destructive, two-dimensional histological techniques. Contrast-enhanced micro-computed tomography (micro-CT) was recently demonstrated to enable non-destructive, three-dimensional (3-D) detection of microdamage in machined cortical and trabecular bone specimens in vitro. However, the accumulation of microdamage in whole bones is influenced b...

متن کامل

Contrast Agents for Micro-Computed Tomography of Microdamage in Bone

Accumulation of microdamage during fatigue can lead to increased fracture susceptibilityin bone. Current techniques for imaging microdamage in bone are inherently destructiveand two-dimensional. Therefore, the objective of this study was to image the accumulationof fatigue microdamage in cortical bone using micro-computed tomography (micro-CT)with a barium sulfate (BaSO4) contra...

متن کامل

Detection of Fatigue Microdamage in Human Cortical Bone Using Micro-Computed Tomography

INTRODUCTION: Conventional techniques used to image microdamage in cortical bone require the preparation of many histologic sections which is inherently invasive, destructive, two-dimensional, and tedious [1]. These limitations inhibit evaluation of the effects of microdamage on whole bone strength and prohibit detection of microdamage in vivo. Therefore, micro-computed tomography (micro-CT) ha...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:
  • Journal of the mechanical behavior of biomedical materials

دوره 4 3  شماره 

صفحات  -

تاریخ انتشار 2011